Custom Peptides
Cayman Chemical SencIphylIn 10mg
An alkaloid with diverse biological activities; induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner; cytotoxic to HepG2 cells (IC20 = 0.66 mM); dietary administration induces sex-linked recessive lethality in male Drosophila; increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver at 80 mg/kg
Cayman Chemical ACTH7-38humntrIfluor 10mg
A peptide fragment of ACTH and an antagonist of MC2R; inhibits ACTH-induced corticosterone production in isolated rat adrenal cells at 0.455 or 4.55 µM; inhibits ACE1 (IC50 = 750 nM for the dog enzyme); inhibits basal cAMP secretion by isolated rat inner adrenocortical cells at 1 µM; induces hypotension in normotensive dogs (ED50 = 0.109 nmol/kg)
Cayman Chemical Scutlaa bacalns Ngltn 10mg
A flavonoid with diverse biological activities; inhibits biofilm formation by S. aureus, B. subtilis, P. aeruginosa, and E. coli at 32 UG/ml; rinduces cytotoxicity in SW460 and DLD-1 cancer cells (IC50s = 29.41 and 30.93 µM, respectively) but not HT-29 or HepG2 cancer cells (IC50s = >40 µM for both); decreases LPS-induced NO production and secreted TNF-α and IL-1β levels in J774A.1 macrophages at 0.01 µM; alone and in combination with NGF increases neurite outgrowths, levels of GAP43, and decreases serum deprivation-induced death in PC12 cells at 10 µM
Cayman Chemical GC7sulfate 10mg
A deoxyhypusine synthase inhibitor (Ki = 9.7 nM); inhibits the production of hypusine in CHO cells at 1 µM; inhibits activation of eIF5A2 and enhances the cytotoxicity of doxorubicin in Huh7 and HepG2 cells at 20 µM; reduces tumor growth in a Melan-a Tm5 murine melanoma model at 0.9 mg/kg
Cayman Chemical 1 2DIlInoleoyl3aLInolenoy 10mg
A triacylglycerol; has been found in corn and soybean oils
Cayman Chemical ORG 12962hydrochlorIde 10mg
A 5-HT2C receptor agonist (EC50 = 97.72 nM in a FLIPR-based intracellular calcium assay using CHO-K1 cells expressing the human receptors); selective for 5-HT2C over 5-HT2A and 5-HT2B receptors (EC50s = 419.87 and 524.81 nM, respectively)
Cayman Chemical 1MyrIstoyl2PalmItoyl3But 10mg
A triacylglycerol containing myristic, palmitic, and butyric acids at the sn-1, sn-2, and sn-3 positions, respectively; has been detected in human breast milk
Cayman Chemical L-Valn-d8 10mg
An internal standard for the quantification of L-valine by GC- or LC-MS
Cayman Chemical TDFAtrIfluoroacetate salt 10mg
An inhibitor of JNK (IC50 280 nM) competitive for JNK1 binding with pepJIP1 (IC50 500 nM) selective for JNK over p38a mTOR and PI3Ka inhibits c-Jun phosphorylation induced by TNF-a (EC50 12 4 UM) restores insulin sensitivity in a mouse model of type 2 diabetes when administered at 25 mg/kg 30 minutes prior to insulin reduces human prostate strip contractions induced by phenylephrine or norepinephrine when applied at 30 UM and reduces phosphorylation of c-Jun a JNK substrate
Cayman Chemical CetrorelIxacetate 10mg
A synthetic peptide GnRHR antagonist (Kd = 0.2 nM); inhibits [D-Trp6]GnRH-induced activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells (IC50 = 1.2 nM); reduces tumor volume and serum luteinizing hormone levels by 35% and 50% of control, respectively, in a human epithelial ovarian cancer mouse xenograft model at 60 μg per day; increases PMF survival in ovaries in cyclophosphamide treated mice at 0.5 mg/kg
Cayman Chemical 6-EAPBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; intended for research and forensic applications
Cayman Chemical 2 3DImethylmethcathInonhy 10mg
A potential designer drug that is structurally related to 4-MMC; intended for research and forensic applications
Cayman Chemical EpIpregnolon 10mg
A neurosteroid and an active metabolite of pregnenolone; inhibits spontaneous contractions in myometrial strips isolated from at-term pregnant women (IC50 = 156 µM); decreases operant alcohol self-administration in rats at 10 and 20 mg/kg
